Sleeping sickness (lyrics) - YouTube

City and Colour - Hope For Now (Lyrics) - YouTube

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A lyric video for "Hope For Now" by City and Colour. Taken from the album "Little Hell".

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city and colour- sleeping sickness (lyrics) - YouTube

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Uploaded on Aug 11, 2010
lyrics to city and colour sleeping sickness, i dont own any of the lyrics, or music :-) Sorry for the long silent outro..

Encephalitis lethargica - Wikipedia, the free encyclopedia

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Encephalitis lethargica or von Economo disease is an atypical form of encephalitis. Also known as "sleepy sickness" (though different from the sleeping sickness transmitted by the tsetse fly), it was first described in 1917 by the neurologist Constantin von Economo[1][2] and the pathologist Jean-René Cruchet.[3] The disease attacks the brain, leaving some victims in a statue-like condition, speechless and motionless.[4] Between 1915 and 1926,[5] an epidemic of encephalitis lethargica spread around the world; no recurrence of the epidemic has since been reported, though isolated cases continue to occur.[6][7]

Symptoms[edit]

Encephalitis lethargica is characterized by high fever, sore throat, headachelethargydouble vision, delayed physical and mental response, sleep inversion and catatonia.[4] In severe cases, patients may enter a coma-like state (akinetic mutism). Patients may also experience abnormal eyemovements ("oculogyric crises"),[8] parkinsonism, upper body weakness, muscular pains, tremors, neck rigidity, and behavioral changes including psychosisKlazomania (a vocal tic) is sometimes present.[9]
Postencephalitic parkinsonism may develop after a bout of encephalitis, more commonly in the post-encephalitic phase and often after a latent period of several years.
The cause of encephalitis lethargica is not known for certain.[10]
Research in 2004 suggested that the disease is due to an immune reaction. In this study, many of the people with encephalitis lethargica had experienced recent pharyngitis and the authors found some evidence linking the reaction to prior streptococcal throat. They hypothesised that encephalitis lethargica, Sydenham's chorea and PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) are mediated by variations of the post-streptococcal immune response.[4]
There is also some evidence of an autoimmune origin with antibodies (IgG) from patients with encephalitis lethargica binding to neurons in the basal ganglia and mid-brainWestern immunoblotting showed that 95% of encephalitis lethargica patients had autoantibodies reactive against human basal ganglia antigens. By contrast, antibodies reactive against the basal ganglia were found in only 2-4% of child and adult controls (n = 173, P < 0.0001).[4]
Some researchers believe that new data support the influenza hypothesis,[11] while others consider this less likely.[4]
Jang et al. (2009) at St. Jude Children's Research HospitalUSA, discovered that an H5N1 Bird Flu (strain A/VN/1203/1204) infection in mice causes severe loss of tyrosine-hydroxylase positivedopaminergic neurons 60 days after infection by provoking a destructive autoimmune response, thus suggesting the infection by certain strains of flu might increase the risk of Parkinson's disease in humans.[12] While Jang et al. (2009) acknowledge research that shows the virus that caused the1918 flu pandemic (a type A influenza subtype H1N1) unlike H5N1 Bird Flu did not infect the brain, they propose that a distal infection might have provoked an autoimmune mediated destruction of dopaminergic neurons, while leaving no direct evidence of brain infection.[12]

Treatment[edit]

Treatment for encephalitis lethargica in the early stages is patient stabilization, which may be very difficult. There is little evidence so far of a consistent effective treatment for the initial stages, though some patients given steroids have seen improvement.[13] Other patients have been less fortunate, and the disease then becomes progressive, with evidence of brain damage similar to Parkinson's disease. Treatment is then symptomatic. Levodopa (L-DOPA) and other anti-parkinson drugs often produce dramatic responses. However, in most of the patients who were given L-DOPA in the 1960s, the amelioration of the disease was short lived.
The course of encephalitis lethargica varies depending upon complications or accompanying disorders.
The prescription drug zolpidem, commonly used as a sleeping pill, has been reported to be successful at treating encephalitis lethargica.[14][15]

Popular culture[edit]

Hawes, the curate in Agatha Christie's book The Murder at the Vicarage (1930), was described as suffering from this syndrome.
The discovery by Oliver Sacks that L-DOPA could relieve some symptoms was described in his bookAwakenings in 1973. The book was used by Harold Pinter as the basis of his one-act play A Kind of Alaska, performed in 1982 starring Judi Dench. The 1990 film Awakenings starring Robin Williamsand Robert De Niro is also based on the book. The Molly Caldwell Crosby book Asleep (2010) describes the history of the disease and the epidemic of the 1920s.[16] The 2012 novel Umbrella byWill Self centres on the occurrence of this disease and its later treatment with L-DOPA.
The 1980s US post-hardcore band Big Black recorded a song about the encephalitis lethargica epidemic called "L-Dopa" (1987).
The disease plays a prominent role in the first issue of Neil Gaiman's comic book Sandman (as featured in The Sandman: Preludes and Nocturnes, Sandman: Doll's House, and Sandman Vol. 1, 1991); the disease, usually referred to by its nickname "sleepy sickness" and only once by its medical name, is attributed to the imprisonment of the sleep-master Dream in 1916 by an occultist.
Encephalitis lethargica is researched and mentioned in the Canadian television show ReGenesis, in the last few episodes of the second series (2006). The disease is involved in one of the episodes in the American science fiction television show Alphas, called a "A short time in paradise" (2011), in which the antagonist causes Encephalitis lethargica to afflict his victims.
It is described in moderate detail in Peter Cummings' novel The Neuropathology of Zombies, in which a proposed mutated form of the disease is considered as the possible cause of a 'zombie' outbreak.

References[edit]

Encephalitis lethargica. Its sequelae and treatment - Constantin Von Economo, 1931: front page
  1. Jump up ^ synd/3356 at Who Named It?
  2. Jump up ^ K. von Economo. Encepahlitis lethargica. Wiener klinische Wochenschrift, May 10, 1917, 30: 581-585. Die Encephalitis lethargica. Leipzig and Vienna, Franz Deuticke, 1918.
  3. Jump up ^ Cruchet R, Moutier J, Calmettes A. « Quarante cas d'encéphalomyélite subaiguë » Bull Soc Med Hôp Paris 1917;41:614-6.
  4. Jump up to: a b c d e Dale RC, Church AJ, Surtees RA, et al. (2004). "Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity"Brain 127 (Pt 1): 21–33.doi:10.1093/brain/awh008PMID 14570817. 
  5. Jump up ^ "Encephalitis lethargica" at Dorland's Medical Dictionary
  6. Jump up ^ Stryker Sue B. "Encephalitis lethargica: the behavior residuals". Training School Bulletin22 (1925): 152–7. 
  7. Jump up ^ Reid AH, McCall S, Henry JM, Taubenberger JK (2001). "Experimenting on the past: the enigma of von Economo's encephalitis lethargica". J. Neuropathol. Exp. Neurol. 60 (7): 663–70.PMID 11444794. 
  8. Jump up ^ Vilensky JA, Goetz CG, Gilman S (January 2006). "Movement disorders associated with encephalitis lethargica: a video compilation". Mov. Disord. 21 (1): 1–8. doi:10.1002/mds.20722.PMID 16200538. 
  9. Jump up ^ Jankovic J, Mejia NI (2006). "Tics associated with other disorders". Adv Neurol 99: 66.PMID 16536352. 
  10. Jump up ^ McCall S, Vilensky JA, Gilman S, Taubenberger JK (May 2008). "The relationship between encephalitis lethargica and influenza: A critical analysis"J. Neurovirol. 14 (3): 177–85.doi:10.1080/13550280801995445PMC 2778472PMID 18569452. 
  11. Jump up ^ Vilensky JA, Foley P, Gilman S (August 2007). "Children and encephalitis lethargica: a historical review"Pediatr. Neurol. 37 (2): 79–84. doi:10.1016/j.pediatrneurol.2007.04.012.PMID 17675021. 
  12. Jump up to: a b Haeman, Jang; David Boltz; Katharine Sturm-Ramirez; Kennie R. Shepherd; Yun Jiao; Robert Webster; Richard J. Smeyne (2009-08-10). "Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration".Proceedings of the National Academy of Sciences 106 (33): 14063–8.doi:10.1073/pnas.0900096106PMC 2729020PMID 19667183. Retrieved 2009-08-11. 
  13. Jump up ^ Blunt SB, Lane RJ, Turjanski N, Perkin GD (1997). "Clinical features and management of two cases of encephalitis lethargica". Mov. Disord. 12 (3): 354–9. doi:10.1002/mds.870120314.PMID 9159730. 
  14. Jump up ^ Boggan, Steve (September 11, 2006). "Reborn"The Guardian. Retrieved November 25,2012. 
  15. Jump up ^ Sparacino, Diane (2012). "New Awakenings". RN.COM. Retrieved November 25, 2012. 
  16. Jump up ^ Molly Caldwell Crosby. Asleep: The Forgotten Epidemic that Remains One of Medicine's Greatest Mysteries. New York: Berkley Books; 2010.

External links[edit]

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sleeping sickness - Google Search

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  • WHO | Trypanosomiasis, human African (sleeping sickness)

    <a href="http://www.who.int/mediacentre/factsheets/.../en/" rel="nofollow">www.who.int/mediacentre/factsheets/.../en/</a>
    World Health Organization
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    WHO fact sheet on Human African trypanosomiasis, also known as sleeping sickness, a vector-borne parasitic disease. it provides key facts, distribution of the ...
  • Sleeping sickness - Wikipedia, the free encyclopedia

    en.wikipedia.org/wiki/Sleeping_sickness
    Wikipedia
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    Sleeping sickness may refer to: African trypanosomiasis, a parasitic disease of people and animals (usually carried by the tsetse fly in rural areas); Animal ...
  • Sleeping sickness: MedlinePlus Medical Encyclopedia

    <a href="http://www.nlm.nih.gov/.../001362" rel="nofollow">www.nlm.nih.gov/.../001362</a>....
    United States National Library of Medicine
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    Causes. Sleeping sickness is caused by two germs (protozoa), Trypanosoma brucei rhodesiense and Trypanosomoa brucei gambiense. The more severe form ...
  • CDC - African Trypanosomiasis

    <a href="http://www.cdc.gov/.../" rel="nofollow">www.cdc.gov/.../</a>sle...
    United States Centers for Disease Control and Preve...
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    by S Sickness - ‎Cited by 54 - ‎Related articles
    Aug 29, 2012 - African Trypanosomiasis, also known as "sleeping sickness," is caused by microscopic parasites of the species Trypanosoma brucei.
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    Russian Propaganda in Belarus is Alienating Belarusians, Writer Warns 

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    Paul Goble

     

                Staunton, January 14 – Moscow has unleashed a powerful wave of “black propaganda” against Belarus, often using Belarusians who now live in the Russian Federation to do it. But that effort, ostensibly designed to counter Western and Ukrainian propaganda, is alienating Belarusians and making cooperation between the two countries in the union state more difficult.

     

                That is the judgment of Vladimir Abtsugov, a Belarusian writer who wants the union state to succeed, on a phenomenon few have focused on up to now as offered in the current issue of the influential Russian military-political journal “Voyenno-politicheskoye obozreniye” (belvpo.com/ru/47441.html).

     

                Russia and Belarus, he begins, are allies and members of a union state. But that doesn’t mean that they do not have differences and even disputes, especially since “the Belarusian state is at the point of contact between Eastern and Western civilizations” and thus is the site of a permanent ideological struggle.

     

                That is “an objective reality” which no one should ignore, and “since the moment of the acquisition by our country of independence,” Abtsugov argues, “the intensity of the conflict between East and West has steadily grown.”

     

                Most of the propaganda in this conflict comes from the West which always has had the goal of “weakening Russia” and seeks to find “the weak links” among the countries around Russia’s periphery which are friendly to Moscow. And some of it comes from Ukraine, especially in the period since the Maidan.

     

                Moscow and Mensk should be able to solve their differences like friends with talks, “but to the enormous regret [of Belarus] … periodically uses dirty technologies taken from the West’s conduct of information wars,” something that should be “categorically impermissible” and that is in the present case counterproductive.

     

                Russian outlets find this easy to do not only because Moscow has “an incomparably large apparatus of political propaganda” but also because Russians and Russian speakers in Belarus rely on Russian media for much of their news, information and opinion. Tragically, Moscow has used these advantages in a destructive way by conducting itself like “a bull in a china shop.”

     

                “One must not say that such actions are the official position of Russia,” especially since the Russian government and the government media generally act quite correctly. “But a certain part of the Russian media belongs to private corporations which allows the latter to be used for all sorts of ‘delicate’ affairs.”

     

                “These [Russian] corporations support political analysts, economists, experts and journalists who specialize in the Belarusian direction, people like Andrey Suzdaltsev, Pavel Sheremet, Nikolay Radov, and Yury Baranchik and uses them like a battering ram in propaganda wars.”

     

                Baranchik is a good example of this, Abtsugov says. Born in Belarus, he recently moved to Russia and has earned his keep there by “regularly pouring dirt on his country and its leadership,” something he has proved ready and willing to do.  Recently, his employers have asked him to go further and he has even suggested that Belarusians do not exist as a people.

     

                He thus requires that Belarusians forget all their history except that when they have been tied to Russia, a demand that is inherently offensive to the more than 80 percent of the Belarusian population who identify as Belarusians. And it invites responses from them that many Russians would not like.

     

                “For example,” Abtsugov says, “one could assert that the Russian Empire was Russian only by name because Peter I was the first and last emperor who was purely Russian by nationality, and all the rest were in one or another degree Germans. Therefore, tsarist Russia never was an independent state but rather was under concealed foreign rule.”

     

                What can this lead to?  The obvious answer is anger and dissatisfaction with Russia among Belarusians.  While most want good relations with Russia, “ever more often can one hear out of the mouths of ordinary Belarusians [negative statements about Moscow] that one would not have heard earlier.”

     

                That is not just the result of Western or Ukrainian propaganda, he says; it is the result of the work of Russian outlets like the REX news agency, the Foundation for Strategic Culture, “Geopolitika,” “Vzglyad,” KM.ru, Regnum “and many others.” One can only hope that Russia will recognize what these organizations are doing.

     

                “Unfortunately,” Abtsugov says, “the Russian propaganda apparatus is directed at promoting anger” rather than promoting friendship. The latter requires “completely different approaches. National and religious feelings are a very delicate instrument, and one must not allow those with less than clean hands to play on them.”

     

     

     

     
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    In Twitter Hack, Pentagon Learns Perils of Social Media Exposure 

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    Buyers Rush to Snag New Charlie Hebdo Issue

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    There were long lines at Paris newsstands that had copies of the French satirical magazine Charlie Hebdo, which lost eight staff members in a militant Islamist attack on its offices last week.  The latest edition, published Wednesday, features a caricature of a weeping Muslim Prophet Muhammed holding a sign that reads " I am Charlie" -  "All is forgiven. All across the city, copies of the magazine sold out within minutes. Even before dawn outside a busy Paris station, commuters were disappointed that all the Charlie Hebdos were long gone.  “Charlie?” a woman asked a news agent. He shook his head no, all their copies were sold out. Additional copies ordered The printers promised an initial run 3 million copies, compared to their normal print run of about 60,000, but they’re only delivering half a million a day. According to a spokesman for Charlie Hebdo's distributor, high demand Wednesday, prompted an additional 2 million copy print order. “It’s essential to buy it, to support them. And it’s of interest to me what’s in the paper," a retired psychotherapist told VOA. “It’s a great gesture, but we expect much more. Most important is that Charlie continues to exist," Philippe, a train driver said. Emilienne, an administrative secretary had the future in mind as she stood in line to buy the magazine. “To keep it for my grandchildren," she explained. "One day I will be able to say to them ‘See, this happened when you were young. I tell you so that it never happens again.’” Inside the station, as travelers poured off the morning trains, they found signs telling them “Charlie Hebdo is sold out.” Bookstore manager Magalie saved one copy for herself. “We opened at 6 a.m. There were already people in line outside. In less than an hour, all 125 copies we had were gone," she said. Staff members defiantly put a caricature of the Prophet Muhammed on the front page, with the words “All is forgiven” and “I am Charlie.” Inside, they published some of the last editorial cartoons drawn by their colleagues who were killed. People looking to buy the magazine Wednesday didn’t necessarily agree with Charlie Hebdo’s views, but said buying this issue was a form of protest. “A magazine like Charlie Hebdo belongs to a tradition of laughter, derision and seeing the truth in things," noted Christian Delporte, a history professor and expert on political cartoons at the University of Versailles. “Everyone also recognizes that these cartoonists are deeply attached to freedom," he added. Vow to press on And the attack survivors have made clear they will continue with their brand of satire, whose overriding message of freedom of expression is close to the hearts of millions of French people. “In the end, it’s a matter of tolerance. If you don’t want to read Charlie Hebdo, don’t buy it," Delporte said. If Wednesday was any indication, millions of people will be buying it, at least for a while.

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    МЧС формирует 12-ю колонну с помощью для Донецка и Луганска - РБК

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    РБК

    МЧС формирует 12-ю колонну с помощью для Донецка и Луганска
    РБК
    МЧС РФ начало формирование 12-го гуманитарного конвоя для оказания помощи жителям Донецка и Луганска. Об этом сообщил журналистам в среду министр по чрезвычайны ситуациям Владимир Пучков, передает Интерфакс. По словам Пучкова, сейчас согласуются все ...
    МЧС готовит 12-й гуманитарный конвой на ДонбассПолит.ру
    МЧС готовит 12-й гуманитарный конвой для ДонбассаНТВ.ru
    Россия намерена отправить на Донбасс очередной "гумконвой"УНИАН
    Комсомольская правда -Взгляд -Интерфакс
    Все похожие статьи: 46 »

    Reaction to "Charlie Hebdo"

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    Security measures have been heightened as the first post-attack issue of Charlie Hebdo hits newsstands.

    Administrator Of Kazakh Village Stricken With Mysterious Ailment 

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    The governor of a Kazakh village in the northern Aqmola region has been hospitalized with what is being described as a mysterious "sleeping disease."

    Kremlin Foe Navalny Fined $10 For Cutting Ankle Bracelet

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    Russian opposition leader Aleksei Navalny has been convicted of large-scale theft twice and spent many nights in jail after street protests.

    Pro-Kremlin Daily Calls Out Officials For Spending New Year's Abroad

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    A pro-Kremlin newspaper has called out "unpatriotic" bureaucrats who took New Year holidays outside Russia.

    Украина: война продолжается? 

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    Теракт под Волновахой, новая волна мобилизации в украинскую армию - почему так труден путь к миру? Обсуждают...
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